In the mRNA sequence ACUAGaugCAGCUAUCAUGCACCACCAGAGA where t

In the mRNA sequence ACUAGaugCAGCUAUCAUGCACCACCAGAGA, where the lowercase aug is the translation start site, what is the resulting sequence of amino acids if it were translated? 12B If the underlined A is changed to a U, will it change the encoded protein sequence? Explain your answer. What if the underlined C is changed to a U? Explain your answer. What if both changes are made? Explain your answer.

Solution

Answer:

12A).

mRNA-----------ACUAG-aug-CAG-CUA-UCA-UGC-ACC-ACC-AGA-GA

AA---------------------------Met-Gln-Leu-Ser-Cys-Thr-Thr-Arg

12B).\\

mRNA-----------ACUAG-aug-CAG-CUU-UCA-UGC-ACC-ACC-AGA-GA

AA---------------------------Met-Gln-Leu-Ser-Cys-Thr-Thr-Arg

The same amino acid is resulted due to change in the nitrogen base of the mRNA sequence. So it is called as silent mutations

12B).

mRNA-----------ACUAG-aug-CAG-UUA-UCA-UGC-ACC-ACC-AGA-GA

AA---------------------------Met-Gln-Leu-Ser-Cys-Thr-Thr-Arg

The same amino acid is resulted due to change in the nitrogen base of the mRNA sequence. So it is called as silent mutations

12C).

mRNA-----------ACUAG-aug-CAG-UUU-UCA-UGC-ACC-ACC-AGA-GA

AA---------------------------Met-Gln-Phe-Ser-Cys-Thr-Thr-Arg

The different amino acid is resulted due to change in the nitrogen bases of the mRNA sequence. So it is called as missense mutations.