In the Cori cycle when glucose is degraded by glycolysis to

In the Cori cycle, when glucose is degraded by glycolysis to lactate in muscle, the lactate is excreted into the blood and returns to the liver where it is converted back into glucose by gluconeogenesis. For each enzyme below, identify whether it is involved in the glycolysis pathyway, gluconeogenesis pathway, both pathways or neither pathway.

1. glyceraldehyde 3-phosphate dehydrogenase O glycolysis O gluconeogenesis O both O neither 2. glucose-6-phosphatase O glycolysis O gluconeogenesis both O neither 3. alcohol dehydrogenase O glycolysis O gluconeogenesis both neither 4. phosphoenolpyruvate carboxykinase O glycolysis O gluconeogenesis O both 5. phosphofructokinase-1 O glycolysis O gluconeogenesis both O neither 6. phosphoglycerate mutase O glycolysis gluconeogenesis O both neither 7. hexokinase O glycolysis O gluconeogenesis. O both neither 8. pyruvate dehydrogenase O glycolysis gluconeogenesis

Solution

ans.

Glycealdehyde 3 P dehydrogenase is required for glycolysis which is uesd to convert glycealdehyde to 1,3 bis phopho glycerate, it is also present in gluconeogenesis

2. Gluocose 6 P is present in glycolysis also present in gluconeogenesis

3. Alcohol dehydrogense is not present in the glycolysis and not in gluconeogenesis

4. phosphoenol pyruvate carboxykinase is not present in glycolysis but it is present in gluconeogenesis which is used to convert Oxalo acetic acid to Phosphoenol pyruvate

5. phospho fructokinase is present in the glycolysis which is used to convert fructose 6P to fructose 1,6 bis phosphate

6. phospho glycerate mutase is present in glycolysis which is used to convert 3 phosphoglycerate to 2 phosphoglycerate , it is also present in gluconeogenesis

7. Hexokinase is present in glycolysis which is used to convert glucose into glucose 6 P .it is not present in the gluconeogenesis

8. pyruvate dehydrogenase is not present in glycolysis and not in gluconeogenesis