Which factor is most likely to associates with the signal se

Which factor is most likely to associates with the signal sequence of a protein that is targeted to the ER?

a. A chaperone of the Hsp70 family

b. The translocation channel

c. The ribosome

d. Signal recognition particle (SRP)

e. Signal peptidase

Solution

SRP is able to detect signal sequences as they emerge from the ribosome,retards translation to create a time window for ER targeting.,SRP receptor transfers the ribosome nascent chain complex from SRP to the translocon. The Sec61 channel conveys the nascent chain from the ribosome directly into the ER lumen. Sec61 can also insert membrane proteins into the lipid bilayer.So,Signal recognition particle (SRP) is most likely to associates with the signal sequence of a protein that is targeted to the ER.