Matching Choose the best answers for the following prompts R

Matching: Choose the best answers for the following prompts:

Responsible for familial Down Syndrome

Dicentric bridges are common in heterozygotes

Responsible for Burkitt\'s Lymphoma

Responsible for Turner Syndrome

The choices for each:

Monosomic

Paracentric Inversion

Deletion

Duplication

Trisomic

Recipricol Translocation

Robertson Translocation

Pericentric Inversion

Solution

1.     Responsible for Down syndrome - Trisomic

Down syndrome is a chromosomal abnormality by the presence of an extra chromosome on 21, it may be either whole chromosome (trisomy 21) or part of the chromosome. Normal persons have only 46 (23 pairs), but the Down syndrome person have extra copy of chromosome at 21 position (23 pairs + 1). Trisomy 21 caused by meiotic non-disjunction, robertsonian translocation and mosaicism

2.     Dicentric bridges are common in heterozygotes – Paracentric Inversion

Chromosomes involved in a reciprocal translocation between two non-homologus chromosomes typically form quadrivalents. If a chromosome has undergone an inversion in which the centromere is not involved (para centric inversion), a heterozygote for this condition will have a dicentric bridge.

3.     Responsible for Burkitt’s lymphoma – Reciprocal Translocation

4.     Responsible for Turner Syndrome - Monosomic

Turner syndrome is a chromosomal condition that alters development in females in which female is partly or completely missing an ‘X’ chromosome

The genetic alterations –

Monosomy – the complete absence of ‘X’ chromosome, results every cell in the body having only one ‘X’ chromosome

Mosaicism – occurs in cell devision during fetal development, results some body cells having complete two copies of ‘X’ chromosome and other cells have only one copy of the ‘X’ chromosome.