httpwwwjbcorgcontent28697202fullpdfhtml What is the CL5 regi

http://www.jbc.org/content/286/9/7202.full.pdf+html

What is the CL5 region? For the purposes of this study how did the authors define the CL5 region? What amino acids comprise this region? (4 marks)

Solution

CL5 region is the Cytoplasmic Loop 5.

For the purposes of this study, the authors have defined CL5 as For the purposes of this study, we defined CL5 as ex-

tending from 486 (Lysine) - 545 (Leucine)

The amino acids comprising this region are:

Lys ⁵¹³, Lys ⁵¹⁶, Glu ⁵²¹, His¹³⁶⁴ and Arg ¹³⁶⁷