HIV protease activates waterfor a hydrolysis reactions using

HIV protease activates waterfor a hydrolysis reactions using what type of two residues?

Solution

The question deals with the action of mechanism of HIV protease.. The main active site for the lies in the identical sub units which has a sequence of (Asp-Thr-Gly) .. The position of these are (25-26-27) .

As it is a homodimer hence both the Asp(25) residues act as a catalytic site for this.. The water plays an important role in the mechanism where water acts as a Nucleophile..

This water along with the (2 -Asp) residues discussed above brings out the mechanism of breaking or hydrolysis of scissile bonds peptides bonds,(these are covalent bonds which can be broken by enzymes)..!!

The two residues are 2 - Asp which are at position 25..!