The different elements of the genes structure correspond to

The different elements of the gene’s structure correspond to the nucleotides in the sequence as follows:

Pro = promoter region, nucleotides 1-103

E1 = exon 1, nucleotides 104-245

I1 = intron 1, nucleotides 246-375

E2 = exon 2, nucleotides 376-598

I2 = intron 2, nucleotides 599-1448

E3 = exon 3, nucleotides 1449-1709

8. If you were to have a single nucleotide substitution in intron 2, would it be more deleterious to have that substitution occur at nucleotide 600, or at nucleotide 1200? Explain your answer.

Solution

A mutation at the start of intron will be more deleterious because it can disturb the splicing process which may lead to formation of mRNA with introns and may lead to production of abnormal protein. Which means the substitution occur at nucleotide 600 (which is a start for intron 2) will be more Deleterious in compare to the one at 1200 nucleotide.