Homework SourseSome antiD reagents are blends of monoclonal IgM and IgG ant
Some anti-D reagents are blends of monoclonal IgM and IgG anti-D. The major advantage of these monoclonal blends is:
Allow for both direct D testing and indirect antiglobulin testing for weak D with the same anti-D reagent.
Cost savings.
Don\'t get prozone effects.
Don\'t need to use any controls.
The designation of weak D is applied when:
When the anti-D reagent fails to agglutinate the test red cells in the immediate spin test but are subsequently agglutinated when the test is continued throught to the IAT phase.
Is the term now applied to all the previous Du classifications.
The reaction in the anti-D tube is weak, say less than 2+.
When the D antigen only reacts with IgM anti-D.
Which of the following blood group antigens are derived from plasma , rather than being an integral part of the red cell membrane?
Leb, Rg, Ch.
Sda, Rg, Bga.
Fya, Jka, Bga.
K, Lua, Ch.
Which of the following statements is false?
Red cells of the Fy(a-b-) phenotype are resistant to Plasmodium vivax.
Anti-Fya has often been implicated in immediate and delayed haemolytic transfusion reactions.
Both the Fya and Fyb antigens are resistant to treatment with most proteolytic enzymes such as papain, ficin, bromelin, and chymotrypsin.
Fya and Fyb antigen strength may decrease in cells stored in saline, but are well preserved in common donor unit anticoagulant solutions.
Anti-Fya is an uncommon cause of HDN.
| Allow for both direct D testing and indirect antiglobulin testing for weak D with the same anti-D reagent. | ||
| Cost savings. | ||
| Don\'t get prozone effects. | ||
| Don\'t need to use any controls. |
Solution
Answer: Allow for both direct D testing and indirect antiglobulin testing for weak D with the same anti-D reagent
Reason:
Some anti-D reagents are blends of monoclonal IgM and IgG anti-D. The major advantage of these monoclonal blends is this reagent is going to allow both direct D testing & indirect antiglobulin testing for weak D phenotypes with same anti-D reagent. For example, the reagent blend of human monoclonal IgM & monoclonal IgG Anti-D from \"murine heterohybridoma lines\" are meticulously suitable for both direct & consequent weak D testing of Red blood cells
