DNA polymerase I has 53 erase activity 53 exonuclease activi

DNA polymerase I has 5\'-3\' erase activity, 5\'-3\' exonuclease activity, and 3\'-5\' exonuclease activity necessary for DNA replication. Mutations in the gene that encodes DNA polymerase l may cause the enzyme to lose these activities. Match the consequence of a loss-of-function mutation in DNA polymerase l to the corresponding lost activity. Lost 5\'-3\' polymerase activity Lost 5\'-3\' exonuclease activity Lost 3\'-5\' exonuclease activity No RNA primer removal during DNA replication Decreased polymerase fidelity No double helix denaturation Unstable strand separation within the replication bubble No DNA synthesis to fill gaps caused by removing RNA primers

Solution

Loss of function means losing their original function to result in an abnormal activity.

1) Loss of function of 5\' - 3\' polymerase activity results in No DNA synthesis to fill gaps caused by removing RNA primers.

2) Loss of function of 5\' - 3\' exonuclease activity results in No RNA primer removal during DNA replication.

3) Loss of function of 3\' - 5\' exonuclease activity results in decreased polymerase fidelity.