Which of the following pairs provides a costimulatory signal

Which of the following pairs provides a costimulatory signal (signal 2) to B cells?

a. T cell CD40: B cell CD40L

b. T cell B7-1 and B7-2: B cell CD28

c. B cell CD40: T cells CD40L

d. T cell CTLA4: B cell B7-1 and B7-2

e. T cell CD28: B cell B7-1 and B7-2

Solution

e. T cell CD28: B cell B7-1 and B7-2

CD28 known as Cluster of Differentiation 28 is one of the proteins expressed on T cells that provides co-stimulatory signals for T-cell activaion and survival.

B7-1 also known as CD80 (cluster of Differentiation 80) is a protein found on Dentritic cells, activated Bcells and monocytes that provides a costimulatory signal for T cell activation and survival.

B7-2 also known as CD86 (cluster of differentiation 86) is a protein expressed on antigen presenting cells that provides co-stimulatory signals required for T cell activation and survival.