Which of the following statements about fat digestion and ab

Which of the following statements about fat digestion and absorption is correct?

a) Pancreatic lipase is a lipid soluble enzyme that hydrolyzes free fatty acids.

b) Micelles are soluble clusters of bile acids, phospholipids, free fatty acids and monoglycerides that are actively transported into the enterocyte.

c) Once absorbed into the enterocyte, free fatty acids are processed by the endoplasmic reticulum into monoglycerides.

d) After packaging in the Golgi, chylomicrons are released across the basolateral surface of the enterocyte, and enter the lymphatic system by diffusing into lacteals.

e) When micelles are formed they are very stable and don’t break down.

Solution

Correct answer for your query is (B)

Explanation:

The digestive enzyme, lipase, is water soluble and can only work at the surface of fat globules. Digestion is greatly aided by emulsification, the breaking up of fat globules into much smaller emulsion droplets. Bile salts and phospholipids areamphipathic molecules that are present in the bile. Motility in the small intestine breaks fat globules apart into small droplets that are coated with bile salts and phospholipids, preventing the emulsion droplets from re-associating.

As monoglycerides and fatty acids are liberated through the action of lipase, they retain their association with bile acids and complex with other lipids to form structures calledmicelles. Micelles are essentially small aggregates (4-8 nm in diameter) of mixed lipids and bile acids suspended within the ingesta. As the ingesta is mixed, micelles bump into the brush border of small intestinal enterocytes, and the lipids, including monoglyceride and fatty acids, are taken up into the epithelial cells.

\"The major products of lipid digestion - fatty acids and 2-monoglycerides - enter the enterocyte by simple diffusion across the plasma membrane.\"

Once inside the enterocyte, fatty acids and monoglyceride are transported into the endoplasmic reticulum, where they are used to synthesize triglyeride. Beginning in the endoplasmic reticulum and continuing in the Golgi, triglyceride is packaged with cholesterol, lipoproteins and other lipids into particles calledchylomicrons.

Chylomicrons are extruded from the Golgi into exocytotic vesicles, which are transported to the basolateral aspect of the enterocyte. The vesicles fuse with the plasma membrane and undergo exocytosis, dumping the chylomicrons into the space outside the cells.