The infected salivary glands contain infiltrating neutrophil

The infected salivary glands contain infiltrating neutrophils that release IFN-gamma. How does IFN-gamma stimulate an adaptive immune response? The salivary glands also contain antibodies that bind and neutralize (deactivate) the MCMV virus. What immunoglobulin (lg) isotype(s) of antibodies do you expect to find in. The infected salivary gland? infected mouse\'s blood? The MCMV virus strain encodes a virulence protein that reduces expression of MHC I molecules on the surface of infected cells. Briefly explain why this might make a virus-infected cells. Briefly explain why this might make a virus-infected cell less/More (circle) susceptible to T lymphocyte (CD8+CTL) Reponses? Immune cells infiltrating infected salivary glands are observed by histology (image below). Under biosafe conditions, you dissect salivary glands from an MCMV-infected mouse and separate the infiltrating CD45+ immune cells; T lymphocytes (CTL) and natural killer (NK) cell by flow cytometry.

Solution

A. Interferon gamma (IFN) is a cytokine of type second-class interferons. That Cytokine produces by CD4 and CD8 T cells as under adaptive immune system. The protein is a dimer and binds to its receptor placed in viral and microbial cells. That helps in the triggering of cellular response.

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B. In the infected salivary gland, we would find immunoglobulin A.

In the infected mouse’s blood, we would find immunoglobulin M.

C. The function of MHC class I molecules is to show the virulent particles via the expression of their proteins. Those proteins then recognize by T cells and the further process of immune system starts. Therefore, if the expression of MHC I molecules reduces, the infected cells will less susceptible to T cells.