In a typical sequence which of these stages of extravasation

In a typical sequence, which of these stages of extravasation occurs last? Tumor cells break through the capillary basement membrane. Platelets associate with a cancer cell. Proteases degrade the microthrombus. A cancer cell proliferates within the capillary. Which of the following is true about metastases? Most micrometastases in patients grow rapidly to several millimeters or more. Anti-cytokeratin antibodies can be used to detect micrometastases in the bone marrow. Intravasation is often considered the rate limiting step of the invasion metastasis cascade. Micrometastases that fail to grow into full metastases typically do not survive long in secondary sites. Which of the following is true of the EMT? Cells that have undergone an EMT have reduced levels of Beta-catenin Epithelial cells that undergo an EMT have changes in gene expression but cell morphology remains relatively unchanged. Wounding prevents EMT in epithelial tissues. Cells that have undergone an EMT typically repress expression of E-cadherin.

Solution

4 a) The correct option is 4 a since by breaking through the basement membrane the cancer cells enter the seconday sites or other other organs.

5) the correct option is b. This is because the monoclonal antibodies recognizing the human cytokeratin component is the most suitable agent because of its negative reaction with the bone marrow samples with non carcinoma pateints. It is highly specific in detection

6) The correct option is d. Reduction of E-cadherin reduces cell to cell adhesion thereby promoting EMT