How does telomere length relate to replicative senescence Wh

How does telomere length relate to replicative senescence? What is the role of telomerase?

Solution

Telomere is a portion of repetitive nucleotide sequences at each end of chromosome. This structure playing vital role in protecting chromosome end from deterioration or fusion with nearby chromosomes. Some cells cannot divide indefinitely due to replicative senescence. The telomere shortening is correlated with replicative senescence well. The telomere length serve as a mitotic clock for the cellular replicative life span.

Telomerase playing vital role in protecting chromosome end from damage . Telomerase add species dependent telomere sequence at the 3\' end of the telomere. There by telomerase elongates telomeres. As telomere elongates, end of chromosome will be protected from external fusion. The telomerase enzyme carries its own RNA molecule which is used as a template during the process of telomere elongation.