A female carrier of TaySachs wants to have a child with a ma

A female carrier of Tay-Sachs wants to have a child with a male carrier for Tay-Sachs. Tay-Sachs is inherited in an autosomal recessive manner. Using the letters \"T\" and T fill out the following table.

Solution

Autosomal recessive conditions are associated with non sex chromosomes and the disease allele must be present in homozygous condition to inflict the disease. Tay-Sachs is a sphingolipidoses associated with mutation in the HEXA gene situated on the chromosome 15. A defective copy of both the allele for HEXA gene will lead to Tay sachs. Lets say that the wild type HEXA gene is T and defective gene is t.

genotype of Mother - Tt; phenotype of mother- carrier

genotype of father-Tt; phenotype of father- carrier

Cross between the two:

Parents: Tt X Tt

offsprings: TT; Tt; Tt; tt

	Female	Male
Genotype	TT; Tt; Tt; tt	TT; Tt; Tt; tt
Phenotype	Normal; carrier; carrier; affected	Normal; carrier; carrier; affected
Genotypes of sperm/ova	Same as the individual	same as the individual