3The Notch receptor also contains a series of EGFlike repeat

3.The Notch receptor also contains a series of EGF-like repeats. I have been doing my homework and reading about EGF repeats. Integrins and laminins also contain EGF like repeats. Integrins and laminins are static structural proteins and not enzymes. Integrins are transmembrane proteins on animal cells that interact/bind laminins. Laminins make up the mortar between cells along with collagen. So integrins and lamins with collagen hold cells in their place like glue. Repeats are often found in very different protein families that are often unrelated in biological function and in the remainder of the protein fold. This can be because the repeating fold forms a biochemically functional unit with a similar molecular role although the proteins are involved in separate processes and not closely related by molecular evolution. What might be true based upon this knowledge? Pick ALL that apply. there is more than one answer please

A.

EGF-like repeats are involved in protein-protein interactions.

B.

EGF-like repeats are involved in quarternary complexes

C.

Notch and Delta are involved in holding cells to the extracellular matrix, i.e. a part of the mortar.

D.

EGF repeats have no role in protein interactions

E.

EGF repeats are frequently the position of an enzyme\'s active site.

F.

EGF-like repeats on separate proteins may interact together.

Solution

Based on the information given in the paragraph, the statements in options A, B, and F appear to be true.

Integrins and laminins contain EGF like repeats, and integrins interact/bind laminins. Moreover, The Notch receptor also contains a series of EGF-like repeats. Thus, EGF-like repeats are likely to be involved in protein-protein interactions (option A).

A quaternary (not QUARTERNARY!) complex is the arrangement of multiple folded protein subunits within a multi-subunit complex. Since EGF-repeats are \"repeats\", they may form multiple interfaces for interactions/ binding with different proteins at a time. Thus, it is likely that EGF-like repeats are involved in quarternary complexes (option B).

EGF-like repeats occur on different types of proteins that interact with one another. For example, they occur on both integrins and laminins, which interact with each other. Thus, it is possible that such proteins may interact with one another at their EGF-repeats (option F).